Siamak Alizadeh  , Abolghasem Esmaeili, Jaleh Barar , Yadollah Omidi*
Optogenetics approaches can provide us with outstanding tool to extend our understanding of how cells perceive, respond, and behave in meeting with complex signals, particularly in terms of cancer evasion from the anticancer immune system functions.
|
Soheila Rostami , Farzaneh Tafvizi* , Hamid Reza Kheiri Manjili
The findings suggest that F-Lys-TMX NPs are more effective and have the potential for cell proliferation inhibition and apoptosis induction compared to the TMX. Hence, F-Lys-TMX NPs can be considered as an anti-cancer agent against MCF-7 breast cancer cells.
|
Yosef Masoudi-Sobhanzadeh* , Hosein Esmaeili , Ali Masoudi-Nejad*
The required data, including proteins and enzymes, are divided into smaller parts and are mined using the existing processors. The proposed method computes the alignment similarity between the existing proteins and SARS-CoV-2’s proteins based on the proposed fuzzy logic system.
|
Sepideh Sheshpari , Mahnaz Shahnazi, Shahin Ahmadian, Mohammad Nouri, Mehran Mesgari Abbasi, Rahim Beheshti, Reza Rahbarghazi, Ali Honaramooz, Mahdi Mahdipour*
The administration of c-Kit+ cells can modulate angiogenesis and pathological changes, leading to the rejuvenation of ovarian function of a rat model of premature menopause.
|
Mohammad Azadbakht , Ali Sayadmanesh, Naghme Nazer, Amirhossein Ahmadi, Sara Hemmati, Hoda Mohammadzade, Marzieh Ebrahimi, Hossein Baharvand, Babak Khalaj, Mahmoud Reza Aghamaali* , Mohsen Basiri*
PRDM1/BLIMP1 expression is increased during differentiation from naïve to effector T cell.CRISPRi-mediated suppression of this transcription factor in ex vivo-expanded primary human T cellsresulted in increased central memory phenotype in human T cells.
|
Mohammad Hasan Soheilifar , Majid Pornour , Massoud Saidijam, Rezvan Najafi, Farid Azizi Jalilian, Hoda Keshmiri Neghab, Razieh Amini*
MiR-1290 through suppression of THBS1 and DKK3 could activate PI3K/AKT pathway. Moreover, DKK3 and SCAI inhibition might induce wnt/β-catenin signaling pathway. Hence, regulatory interplay between miR-1290 and its targets may promote oncogenesis and angiogenesis in CRC through PI3K/AKT and Wnt/ β-catenin signaling pathways activation.
|
Ysrafil Ysrafil* , Zulfiayu Sapiun , Indwiani Astuti , Mohammad Anas Anasiru, Nangsih Sulastri Slamet , Hartati Hartati , Fadli Husain, Sukmawati Ahmad Damiti
The two designed and constructed multiepitope vaccine have good characteristics and may have the potential to activate humoral and cellular immune responses against SARS-CoV-2. Further research is worth considering to confirm the findings of this study.
|
Forough Shams , Hadi Bayat, Omid Mohammadian, Somayeh Mahboudi, Hassan Vahidnezhad, Mohsen Soosanabadi, Azam Rahimpour*
|
Aleksandr L. Urakov* , Natalya A. Urakova, Ilnur I. Yagudin, Milena D. Svetova, Darya O. Suntsova
The purpose of this letter was to present a model for evaluating the biological activity of drugs, which can become a new vector for the development of effective ways to increase blood oxygenation across pulmonary and save the lives of patients with severe atypical pneumonia complicated by respiratory obstruction in COVID-19.
|