Siamak Alizadeh ORCID, Abolghasem Esmaeili, Jaleh Barar ORCID, Yadollah Omidi* ORCID
BioImpacts. 2022;12(4): 295-299. doi: 10.34172/bi.2021.22179
PMCID: PMC9376163     PMID: 35975208     Scopus ID: 85137389032    
Optogenetics approaches can provide us with outstanding tool to extend our understanding of how cells perceive, respond, and behave in meeting with complex signals, particularly in terms of cancer evasion from the anticancer immune system functions.
Original Research
Soheila Rostami ORCID, Farzaneh Tafvizi* ORCID, Hamid Reza Kheiri Manjili
BioImpacts. 2022;12(4): 301-313. doi: 10.34172/bi.2021.23337
PMCID: PMC9376161     PMID: 35975200     Scopus ID: 85138644192    
The findings suggest that F-Lys-TMX NPs are more effective and have the potential for cell proliferation inhibition and apoptosis induction compared to the TMX. Hence, F-Lys-TMX NPs can be considered as an anti-cancer agent against MCF-7 breast cancer cells.
Original Research
Yosef Masoudi-Sobhanzadeh* ORCID, Hosein Esmaeili ORCID, Ali Masoudi-Nejad* ORCID
BioImpacts. 2022;12(4): 315-324. doi: 10.34172/bi.2021.40
PMCID: PMC9376160     PMID: 35975205     Scopus ID: 85137344477    
The required data, including proteins and enzymes, are divided into smaller parts and are mined using the existing processors. The proposed method computes the alignment similarity between the existing proteins and SARS-CoV-2’s proteins based on the proposed fuzzy logic system.
Original Research
Sepideh Sheshpari ORCID, Mahnaz Shahnazi, Shahin Ahmadian, Mohammad Nouri, Mehran Mesgari Abbasi, Rahim Beheshti, Reza Rahbarghazi, Ali Honaramooz, Mahdi Mahdipour* ORCID
BioImpacts. 2022;12(4): 325-335. doi: 10.34172/bi.2021.23499
PMCID: PMC9376162     PMID: 35975202     Scopus ID: 85138756745    
The administration of c-Kit+ cells can modulate angiogenesis and pathological changes, leading to the rejuvenation of ovarian function of a rat model of premature menopause.
Original Research
Mohammad Azadbakht ORCID, Ali Sayadmanesh, Naghme Nazer, Amirhossein Ahmadi, Sara Hemmati, Hoda Mohammadzade, Marzieh Ebrahimi, Hossein Baharvand, Babak Khalaj, Mahmoud Reza Aghamaali* ORCID, Mohsen Basiri* ORCID
BioImpacts. 2022;12(4): 337-347. doi: 10.34172/bi.2021.23522
PMCID: PMC9376159     PMID: 35975204     Scopus ID: 85137404752    
PRDM1/BLIMP1 expression is increased during differentiation from naïve to effector T cell.CRISPRi-mediated suppression of this transcription factor in ex vivo-expanded primary human T cellsresulted in increased central memory phenotype in human T cells.
Original Research
Mohammad Hasan Soheilifar ORCID, Majid Pornour ORCID, Massoud Saidijam, Rezvan Najafi, Farid Azizi Jalilian, Hoda Keshmiri Neghab, Razieh Amini* ORCID
BioImpacts. 2022;12(4): 349-358. doi: 10.34172/bi.2021.23571
PMCID: PMC9376166     PMID: 35975203     Scopus ID: 85130482955    
MiR-1290 through suppression of THBS1 and DKK3 could activate PI3K/AKT pathway. Moreover, DKK3 and SCAI inhibition might induce wnt/β-catenin signaling pathway. Hence, regulatory interplay between miR-1290 and its targets may promote oncogenesis and angiogenesis in CRC through PI3K/AKT and Wnt/ β-catenin signaling pathways activation.
Original Research
Ysrafil Ysrafil* ORCID, Zulfiayu Sapiun ORCID, Indwiani Astuti ORCID, Mohammad Anas Anasiru, Nangsih Sulastri Slamet ORCID, Hartati Hartati ORCID, Fadli Husain, Sukmawati Ahmad Damiti ORCID
BioImpacts. 2022;12(4): 359-370. doi: 10.34172/bi.2022.23769
PMCID: PMC9376164     PMID: 35975206     Scopus ID: 85138027836    
The two designed and constructed multiepitope vaccine have good characteristics and may have the potential to activate humoral and cellular immune responses against SARS-CoV-2. Further research is worth considering to confirm the findings of this study.
Forough Shams ORCID, Hadi Bayat, Omid Mohammadian, Somayeh Mahboudi, Hassan Vahidnezhad, Mohsen Soosanabadi, Azam Rahimpour* ORCID
BioImpacts. 2022;12(4): 371-391. doi: 10.34172/bi.2022.23871
PMCID: PMC9376165     PMID: 35975201     Scopus ID: 85137393658    
Letter to the Editor
Aleksandr L. Urakov* ORCID, Natalya A. Urakova, Ilnur I. Yagudin, Milena D. Svetova, Darya O. Suntsova
BioImpacts. 2022;12(4): 393-394. doi: 10.34172/bi.2022.23877
PMCID: PMC9376158     PMID: 35975207     Scopus ID: 85138077187    
The purpose of this letter was to present a model for evaluating the biological activity of drugs, which can become a new vector for the development of effective ways to increase blood oxygenation across pulmonary and save the lives of patients with severe atypical pneumonia complicated by respiratory obstruction in COVID-19.