Original Research
Wael A. Mahdi ORCID, Mohammad S. Absar, Suna Choi, Victor C. Yang, Young M. Kwon* ORCID
BioImpacts. 2022;12(6): 479-486. doi: 10.34172/bi.2022.23477
PMCID: PMC9809136     PMID: 36644546     Scopus ID: 85143309781    
The tPA was successfully modified via enzymatic oxidation by GO, resulting in enhanced control of its activity in the prodrug construct. This approach can be applied to other therapeutic glycoproteins.
Original Research
Raja Rajeswari Rajeshkumar ORCID, Banoth Karan Kumar ORCID, Pavadai Parasuraman ORCID, Theivendren Panneerselvam ORCID, Krishnan Sundar ORCID, Damodar Nayak Ammunje ORCID, Sureshbabu Ram Kumar Pandian ORCID, Sankaranarayanan Murugesan ORCID, Shanmugampillai Jeyarajaguru Kabilan ORCID, Selvaraj Kunjiappan*
BioImpacts. 2022;12(6): 487-499. doi: 10.34172/bi.2022.24113
PMCID: PMC9809135     PMID: 36644543     Scopus ID: 85143350606    
The bioactive compounds from Cynodon dactylon potentially degrade the α-Syn aggregation in the brain through in silico molecular docking investigations. A molecular dynamics simulation confirms the stability of the α-Syn-ligand complex.
Original Research
Fatima Molavi ORCID, Mohammad Barzegar-Jalali ORCID, Hamed Hamishehkar* ORCID
BioImpacts. 2022;12(6): 501-513. doi: 10.34172/bi.2022.23733
PMCID: PMC9809140     PMID: 36644544     Scopus ID: 85143373141    
Evaluation of different variables on preparation of Microspheres. F9; Freeze-dried particles prepared by W/O/W emulsion method, F1; Dried particles on the tray at room temperature, F16; Freeze-dried particles prepared by S/O/O emulsion method. W/O/W; Water in oil in water, S/O/O; Solid in oil in oil.
Original Research
Laura Cabeza ORCID, Mazen M. El-Hammadi ORCID, Raul Ortiz ORCID, Maria D. Cayero-Otero, Julia Jiménez-López ORCID, Gloria Perazzoli ORCID, Lucia Martin-Banderas ORCID, Jose M. Baeyens ORCID, Consolación Melguizo* ORCID, Jose Prados ORCID
BioImpacts. 2022;12(6): 515-531. doi: 10.34172/bi.2022.23433
PMCID: PMC9809141     PMID: 36644541     Scopus ID: 85140308481    
These results suggest that our PTX-PLGA NPs could be a suitable strategy for breast cancer therapy, improving antitumor drug efficiency and reducing systemic toxicity without altering its mechanism of action.
Schematic of the microfluidic device, top view and cross section of the middle part of the microfluidic device, tumor cell labeled with the functionalized antibodies with the Fe3O4 PMNPs, surface functionalization of the Si nanowires, SEM images of the middle part of the Si substrate with well-aligned SiNWs, SEM images of the tilted view of cancer cells trapped on the nanowires substrate microfluidic channel.
Original Research
Nasrollah Jabbari ORCID, Maryam Feghhi, Omid Esnaashari, Hamid Soraya, Jafar Rezaie* ORCID
BioImpacts. 2022;12(6): 549-559. doi: 10.34172/bi.2022.23489
PMCID: PMC9809134     PMID: 36644548     Scopus ID: 85143387474    
Treatment of MCF-10a, MCF-7, and MDA-MD-231 cells with Gallic acid resulted in inhibition in the activity of the exosomal secretory pathway. Gallic acid can decrease the expression of genes involved in exosomes biogenesis (Alix and CD63) and secretion (Rab proteins). In addition, Gallic acid can change the expression of autophagy markers (LC3 and P62) in these cells. MVB: multivesicular body.
Short Communication
Maryam Moazeni ORCID, Majid Saeedi ORCID, Hamidreza Kelidari ORCID, Behrad Roohi, Mohammad T Hedayati ORCID, Tahereh Shokohi ORCID, Mojtaba Nabili ORCID, Kofi Asare-Addo ORCID, Ali Nokhodchi* ORCID
BioImpacts. 2022;12(6): 561-566. doi: 10.34172/bi.2022.23825
PMCID: PMC9809133     PMID: 36644547     Scopus ID: 85143320810    
Due to the occurrence of fluconazole resistance to Candida glabrata, four resistant as well as one standard isolates were exposed to fluconazole loaded nanostructured lipid carrier alongside conventional fluconazole. These data represent the possible changes in efflux pumps genes expression.
Alireza Khoshroo* ORCID, Maryamosadat Mavaei, Masoume Rostami, Bahare Valinezhad-Saghezi, Ali Fattahi* ORCID
BioImpacts. 2022;12(6): 567-588. doi: 10.34172/bi.2022.23616
PMCID: PMC9809139     PMID: 36644549     Scopus ID: 85143374987    
This review presents an overview of different recognition elements on an electrochemical platform for the detection of bacteria.
Fatemeh Khonsari ORCID, Mostafa Heydari ORCID, Rassoul Dinarvand ORCID, Mohammad Sharifzadeh ORCID, Fatemeh Atyabi* ORCID
BioImpacts. 2022;12(6): 589. doi: 10.34172/bi.2022.27678
PMCID: PMC9809137     PMID: 36644545     Scopus ID: 85143414627