Azam Safary  , Mostafa Akbarzadeh Khiavi , Rahimeh Mousavi, Jaleh Barar , Mohammad A Rafi*
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Azam Safary , Rezvan Moniri, Maryam Hamzeh-Mivehroud, Siavoush Dastmalchi*
The current study introduces a new and efficient recombinant L-asparaginase (ASPase) enzyme from locally isolated halo-thermotolerant Bacillus. The activity assay of ASPase A1 and ASPase A3 showed that only ASPase A1 is an active and stable homologues enzyme with high substrate affinity toward L-asparagine.
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Mostafa Akbarzadeh Khiavi , Azam Safary , Mohammad Hossein Somi*
Colorectal cancer (CRC) as a malignancy shows high mortality rate worldwide because of metastasis and drug resistance. Targeted multimodal nanosystems (NSs) can be developed and used against CRC with much better clinical outcomes.
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Mostafa Akbarzadeh Khiavi , Azam Safary , Jaleh Barar , Hamed Farzi-Khajeh, Abolfazl Barzegari, Rahimeh Mousavi, Mohammad Hossein Somi* , Yadollah Omidi*
The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.
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Marziyeh Fathi , Azam Safary , Jaleh Barar*
Jaleh Barar (PharmD, PhD) is Professor of Drug Delivery and Targeting. She currently is the chair of the department of Pharmaceutics at the Faculty of Pharmacy, Tabriz university of Medical Sciences. Professor Barar’s research is focused on various aspects of the pharmaceutical cell biology with the particular emphasis on the development of novel drug delivery and targeting strategies to combat cancer.
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Azam Safary , Mostafa Akbarzadeh-Khiavi , Jaleh Barar , Yadollah Omidi*
Professor Yadollah Omidi has a Ph.D. degree in Pharmaceutical Sciences (2003, Cardiff University, UK). He is currently working as a full professorat Nova Southeastern University College of Pharmacy, Florida. He has consecutively been listedamong top 1% highly cited scientists worldwide by WoS-ESI.
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Mostafa Akbarzadeh-Khiavi , Azam Safary , Yadollah Omidi*
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