Khalil EL Khatabi  , Ilham Aanouz, Marwa Alaqarbeh, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine*
Molecular docking was performed to explore the binding affinity of the 12 selected molecules in the target enzyme and then evaluated for in silico ADMET properties. The best hits were subjected to molecular dynamics simulation.
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Letter to the Editor
COVID-19
Yosef Masoudi-Sobhanzadeh*
This letter aims to introduce drug repurposing methods and the existing challenges to detect candidate drugs which may be helpful in controlling COVID-19.
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Jaleh Barar*
The vast knowledge about the pathways that regulate the virus entry and molecular signaling of the pathogenesis of coronavirus are the key factor for the development of de novo nanoscaled diagnostic/therapeutic strategies.
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Prospective Highlights
COVID-19
Morteza Mahmoudi* , Loraleigh Keashly
In this perspective piece we will explore the potential facilitative influence of COVID-19 and specifically responses to it, on bullying behaviors in academic and research environments.
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Mohammad Hossein Ahmadi*
A schematic representation of the application of viral interference phenomenon in prophylaxis of COVID-19. The viral interference is a competition phenomenon by which a primary virus infecting a cell prohibits the infection of the same cell by another (secondary) virus.
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Original Research
COVID-19
Khalil Ansarin , Ramin Tolouian, Mohammadreza Ardalan* , Ali Taghizadieh, Mojtaba Varshochi, Soheil Teimouri, Tahere Vaezi, Hamed Valizadeh, Parviz Saleh, Saeid Safiri , Kenneth R. Chapman
Based on a randomized clinical trial, bromhexine is proposed as a potential therapeutic option in COVID-19. A total of 78 patients with similar demographic and disease characteristics were treated with results showing a significant reduction in ICU admissions.
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Sajad Khiali , Afra Rezagholizadeh , Taher Entezari-Maleki*
In the present perspective piece, three possible mechanisms of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an oncogenic virus in the lung have been discussed.
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Ata Mahmoodpoor , Ali Shamekh, Sarvin Sanaie*
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Yang Han , Zhilong Jia* , Jinlong Shi, Weidong Wang*, Kunlun He*
The enrichment of several other pathogens, immunomodulatory probiotics (lactic acid or butyrate producers), and TMV in the COVID-19 group suggests a complex and active lung microbiota disorder.
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Alireza Farnam*
Alireza Farnam is a Professor of Psychiatry at Tabriz University of Medical Sciences, with main expertise in Personology, Psychanalysis, Neurosciences and Clinical psychiatry research. His recent researches foÂcus on neuro-psychiatry, neuro-philosophy and self-awareness.
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Original Research
COVID-19
Mohammad Mostafa Pourseif , Sepideh Parvizpour, Behzad Jafari, Jaber Dehghani , Behrouz Naghili, Yadollah Omidi*
Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.
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Yosef Masoudi-Sobhanzadeh* , Hosein Esmaeili , Ali Masoudi-Nejad*
The required data, including proteins and enzymes, are divided into smaller parts and are mined using the existing processors. The proposed method computes the alignment similarity between the existing proteins and SARS-CoV-2’s proteins based on the proposed fuzzy logic system.
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Luigi X Cubeddu* , Daisy de la Rosa, Michele Ameruoso
A combination of old age, comorbidities, increased cytokine levels and proarrhythmic drug therapies canexplain the increased arrhythmic events reported in severe COVID-19 disease.
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Maryam Sayahinouri , Sahar Mashayekhi Firouz , Amin Ebrahimi Sadrabadi , Mina Masoudnia , Mahnaz Abdolahi , Fatemeh Jafarzadeh , Meshkat Nouripour , Sana Mirzazadeh , Nazanin Zangeneh , Arsalan Jalili* , Nasser Aghdami
In COVID-19 infection, the various functions of immune cells lead to defense or failure against the virus. Cell therapy is of great importance as a new treatment for COVID-19 infection. Therefore, in this review, we have dealt with the function of immune cells against the SARS-Cov-2 virus and new treatment methods for this disease with the help of different cell types
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Aleksandr L. Urakov* , Natalya A. Urakova, Ilnur I. Yagudin, Milena D. Svetova, Darya O. Suntsova
The purpose of this letter was to present a model for evaluating the biological activity of drugs, which can become a new vector for the development of effective ways to increase blood oxygenation across pulmonary and save the lives of patients with severe atypical pneumonia complicated by respiratory obstruction in COVID-19.
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Danial Mehranfard , Robert C. Speth*
This spotlight briefly describes the CAP and its potential role as a therapeutic target for the treatment of COVID-19 infections using vagus nerve stimulation or selective alpha7 nicotinic acetylcholine receptor agonists.
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Azam Safary , Mostafa Akbarzadeh-Khiavi , Jaleh Barar , Yadollah Omidi*
Professor Yadollah Omidi has a Ph.D. degree in Pharmaceutical Sciences (2003, Cardiff University, UK). He is currently working as a full professorat Nova Southeastern University College of Pharmacy, Florida. He has consecutively been listedamong top 1% highly cited scientists worldwide by WoS-ESI.
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Elina Armani Khatibi , Nastaran Farshbaf Moghimi, Elaheh Rahimpour*
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