Using immunoinformatic tools, a multi-epitope peptide vaccine (consisting of CD8+cytotoxic T lymphocytes epitopes, helper epitopes and adjuvant) was designed to combat the triple-negative breast cancer. The vaccine showed acceptable immunogenicity and potential to stimulate both cellular and humoral immune responses.

Aptamers (Aps) are short single-strand nucleic acids, which can be used as the therapeutic and targeting agent in advanced drug delivery systems. Conjugation of Aps with other entities (siRNA, toxins, drugs, DNAzyme/Ribozymes) provides advanced multifunctional nanosystems for cancer therapy.

Increased expression of TSGA10 associated with the reduced metastasis in the MDA-MB-231 cells. TSGA10 showed interaction with HIF-1α with high affinity. TSGA10 expression is altered under the hypoxia, indicating its potential as a bio-target for cancer therapy.

Based on in vitro and in silico findings, MC is suggested as an important ECMmimicking entity that can support the semi-solid medium and promote the formation of the uniform spheroid in the 3D culture.

Based on in vitro experiments, the anti-cancer effect of the locally isolated L. plantarum was validated through some signaling pathways, including PTEN, Bax, TLR4, and AKT genes.

The current study introduces an efficient ROS-responsive enzyme-based nanobiosystem and its biological impact in colon cancer therapy. Based on physicochemical properties, AuNPs-PEG-RNase A effectively induced apoptosis in SW-480 colon cancer cells and resulted in a significant reduction in cancer cell viability.

Dr. Yadollah Omidi (Pharm.D., Ph.D.) is a Professor of Pharmaceutical Sciences at TUOMS Faculty of Pharmacy, working on advanced multifunctional nanobiosystems. He has worked at Cardiff University and University of Pennsylvania. He has published over 210 papers and 18 book chapters, supervised and mentored over 100 graduate/postgraduate students/researchers.

E. coli Nissle 1917 (EcN) is proposed as an appropriate light-activated vehicle for delivery of anticancer agents to the cancer cells/tissues such colorectal cancer.

A new microfluidic-based method with integrated Au electrodes as a miniaturized detection system in anout-channel approach was developed for the simultaneous quantification of acetaminophen (AP) andphenylephrine (PHE) in pharmaceuticals and the human blood.

Professor Yadollah Omidi has a Ph.D. degree in Pharmaceutical Sciences (2003, Cardiff University, UK) and completed a postdoctoral program (2004) at Cardiff University. He is currently working as a full professor at Nova Southeastern University College of Pharmacy, Florida. Prof. Omidi’s research in advanced targeted diagnosis and therapy of diseases have resulted in over 300 published papers in international journals, 27 book chapters, and a few patents.

Microalgae can consider as a more powerful platform for the production of different types of therapeutic proteins such as hIL-2.

Optogenetics approaches can provide us with outstanding tool to extend our understanding of how cells perceive, respond, and behave in meeting with complex signals, particularly in terms of cancer evasion from the anticancer immune system functions.

The pollen grain of Pistacia vera L. is proposed as a scaffolding building block with the encapsulation capability of bioactive compounds. A modified simple method was developed to create nonallergic hollow pollen grains (HPGs).

Immunodominant T-cell epitopes of SARS-CoV-2 spike protein with the highest population coverage were predicted by analyzing peptide binders and consensus rank (CR) score. Multi-method B-cell epitope prediction approach was used to find B-cell immunodominant regions of spike protein. Upon the high immune-potent regions of the antigen(s), self-amplifying mRNA and peptide-based vaccines were designed.

Mohammad Rafi (Persian: محمد رفیع ) obtained his PhD from University of Montpellier, France, in 1970. Investigating lysosomal storage diseases, he focused on gene therapy of neurodegenerative disorders using globoid cell leukodystrophy (Krabbe disease) animal models. With successful AAVrh10-mediated therapy in animal models, his research is moving towards human clinical trials.

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) functionalized with polyethylene glycol (PEG)and anti-TEM1 antibody fragment (78Fc) and loaded with necrosis-inducing agent shikonin (SHK)(78Fc-PLGA-SHK NPs) is a highly effective immunostimulating nanomedicine against theTEM1-expressing cells for targeted therapy of solid tumors.

Transformation of the academic pharmaceutical and biomedical research centers towards innovative R & D hubs is a dynamic nested complex matter, which can be accomplished via a partnership with pharmaceutical and biomedical manufacturers as well as established and emerging contract research organizations.

Using 3D cell models to understand the etiology and molecular mechanisms underlying auditory disorders holds great potential for developing more targeted and effective novel therapeutics.

Injectable thermosensitive hydrogel (PNIPAAm-g-CS copolymer/gelatin hybrid hydrogel) can be used for osteogenic differentiation of human dental pulp stem cells (hDPSCs).

MG63 and GMS Cell exposure to the control PEO and melted PEO (80°C-treated samples) demonstrated no cell toxicity, however cell exposure to 180°C-treated samples exhibited severe cell toxicity that is attributed to the byproducts remained of the PEO thermo-oxidative degradation. Cytotoxicity of the manipulated PEO is independent of its molecular weight.

Owing to their unique advantages, mesoporous silica nanoparticles (MSNPs) have attracted much attention for drug delivery and targeting. In the current study, MSNPs were fabricated, PEGylated, loaded with sunitinib, and conjugated with mucin-16 aptamer to target CA125 on ovarian cancer cells.

Professor Yadollah Omidi has a Ph.D. degree in Pharmaceutical Sciences (2003, Cardiff University, UK). He is currently working as a full professorat Nova Southeastern University College of Pharmacy, Florida. He has consecutively been listedamong top 1% highly cited scientists worldwide by WoS-ESI.